PSMA6

Proteasome (prosome, macropain) subunit, alpha type, 6
File:PBB Protein PSMA6 image.jpg PDB rendering based on 1iru.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1iru​
Identifiers
Symbols	PSMA6 ; IOTA; MGC22756; MGC2333; MGC23846; PROS27; p27K
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2085
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PSMA6 208805 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Proteasome (prosome, macropain) subunit, alpha type, 6, also known as PSMA6, is a human gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.

Further reading

• Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.CS1 maint: Multiple names: authors list (link)
• Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. PMID 12914693.
• DeMartino GN, Orth K, McCullough ML; et al. (1991). "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous". Biochim. Biophys. Acta. 1079 (1): 29–38. PMID 1888762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bey F, Silva Pereira I, Coux O; et al. (1993). "The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family". Mol. Gen. Genet. 237 (1–2): 193–205. PMID 7681138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kristensen P, Johnsen AH, Uerkvitz W; et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nederlof PM, Wang HR, Baumeister W (1996). "Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12060–4. PMID 8618844.CS1 maint: Multiple names: authors list (link)
• Bureau JP, Olink-Coux M, Brouard N; et al. (1997). "Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens". Exp. Cell Res. 231 (1): 50–60. doi:10.1006/excr.1996.3453. PMID 9056411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.CS1 maint: Multiple names: authors list (link)
• Gerards WL, de Jong WW, Bloemendal H, Boelens W (1998). "The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits". J. Mol. Biol. 275 (1): 113–21. doi:10.1006/jmbi.1997.1429. PMID 9451443.CS1 maint: Multiple names: authors list (link)
• Henry L, Baz A, Château MT; et al. (1998). "Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells". Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. 15 (3): 131–44. PMID 9497851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. PMID 9811770.
• Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.CS1 maint: Multiple names: authors list (link)
• Elenich LA, Nandi D, Kent AE; et al. (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics. 49 (10): 835–42. PMID 10436176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.
• Kleijnen MF, Shih AH, Zhou P; et al. (2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Mol. Cell. 6 (2): 409–19. PMID 10983987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Y, Longo DL, Ferris DK (2001). "Polo-like kinase interacts with proteasomes and regulates their activity". Cell Growth Differ. 12 (1): 29–37. PMID 11205743.CS1 maint: Multiple names: authors list (link)
• Engidawork E, Juranville JF, Fountoulakis M; et al. (2002). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome". J. Neural Transm. Suppl. (61): 117–30. PMID 11771738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sjakste T, Sjakste N, Scherrer K (2002). "Exon/intron organisation of human proteasome PROS-27 K gene". DNA Seq. 12 (4): 261–5. PMID 11924531.CS1 maint: Multiple names: authors list (link)