PSCD2

Pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)
File:PBB Protein PSCD2 image.jpg PDB rendering based on 1pbv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1pbv​, 1r8m​, 1r8q​, 1r8s​, 1s9d​, 1u27​, 1u29​
Identifiers
Symbols	PSCD2 ; ARNO; CTS18; CTS18.1; PSCD2L; SEC7L; Sec7p-L; Sec7p-like
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32116
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PSCD2 209158 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2), also known as PSCD2, is a human gene.

Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kolanus W, Nagel W, Schiller B; et al. (1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. PMID 8706128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chardin P, Paris S, Antonny B; et al. (1997). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. doi:10.1038/384481a0. PMID 8945478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meacci E, Tsai SC, Adamik R; et al. (1997). "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1745–8. PMID 9050849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. PMID 9417041.CS1 maint: Multiple names: authors list (link)
• Mossessova E, Gulbis JM, Goldberg J (1998). "Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase". Cell. 92 (3): 415–23. PMID 9476900.CS1 maint: Multiple names: authors list (link)
• Cherfils J, Ménétrey J, Mathieu M; et al. (1998). "Structure of the Sec7 domain of the Arf exchange factor ARNO". Nature. 392 (6671): 101–5. doi:10.1038/32210. PMID 9510256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ (1998). "Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase". Curr. Biol. 8 (8): 463–6. PMID 9550703.CS1 maint: Multiple names: authors list (link)
• Kim HS (1999). "Assignment of the human cts18.1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel". Cytogenet. Cell Genet. 83 (1–2): 43. PMID 9925920.
• Santy LC, Frank SR, Hatfield JC, Casanova JE (1999). "Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch". Curr. Biol. 9 (20): 1173–6. doi:10.1016/S0960-9822(00)80019-6. PMID 10531036.CS1 maint: Multiple names: authors list (link)
• Ogasawara M, Kim SC, Adamik R; et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. PMID 10652308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith JS, Tachibana I, Pohl U; et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitale N, Pacheco-Rodriguez G, Ferrans VJ; et al. (2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macia E, Paris S, Chabre M (2000). "Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids". Biochemistry. 39 (19): 5893–901. PMID 10801341.CS1 maint: Multiple names: authors list (link)
• Lee SY, Pohajdak B (2000). "N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi". J. Cell. Sci. 113 ( Pt 11): 1883–9. PMID 10806099.
• Claing A, Chen W, Miller WE; et al. (2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitano J, Kimura K, Yamazaki Y; et al. (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. PMID 11850456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.CS1 maint: Multiple names: authors list (link)
• Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis SE (2003). "Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2". Cytogenet. Genome Res. 97 (3–4): 171–8. PMID 12438709.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huh M, Han JH, Lim CS; et al. (2003). "Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons". J. Neurochem. 85 (1): 282–5. PMID 12641750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)