PRKAR1B

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.[1][2][3]

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder .[4]

Interactions

PRKAR1B has been shown to interact with AKAP1[5] and PRKAR1A.[5][6]

References

  1. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
  2. Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.
  3. "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
  4. Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. PMID 24722252.
  5. 5.0 5.1 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
  6. Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966.

Further reading



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