POLDIP3

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[1][2]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[2]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.[3]

References

  1. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  2. 2.0 2.1 "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
  3. Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. England. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading