POLA2

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Polymerase (DNA directed), alpha 2 (70kD subunit)
Identifiers
Symbols POLA2 ; FLJ21662; FLJ37250
External IDs Template:MGI HomoloGene48121
RNA expression pattern
File:PBB GE POLA2 204441 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Polymerase (DNA directed), alpha 2 (70kD subunit), also known as POLA2, is a human gene.[1]


References

  1. "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".

Further reading

  • Pollok S, Stoepel J, Bauerschmidt C; et al. (2003). "Regulation of eukaryotic DNA replication at the initiation step". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/ Check |doi= value (help). PMID 12546699.
  • Nasheuer HP, Moore A, Wahl AF, Wang TS (1991). "Cell cycle-dependent phosphorylation of human DNA polymerase alpha". J. Biol. Chem. 266 (12): 7893–903. PMID 1902230.
  • Collins KL, Russo AA, Tseng BY, Kelly TJ (1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J. 12 (12): 4555–66. PMID 8223465.
  • Dantzer F, Nasheuer HP, Vonesch JL; et al. (1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. PMID 9518481.
  • Schneider A, Smith RW, Kautz AR; et al. (1998). "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit". J. Biol. Chem. 273 (34): 21608–15. PMID 9705292.
  • Huang D, Jokela M, Tuusa J; et al. (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. PMID 11433027.
  • Taneja P, Gu J, Peng R; et al. (2002). "A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication". J. Biol. Chem. 277 (43): 40853–61. doi:10.1074/jbc.M208067200. PMID 12181327.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

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