Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.[2]
↑Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID9205841.
↑Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID10896674.
↑Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID12370826.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID10896674.
Chaib H, Rubin MA, Mucci NR, Li L, Day ML, Rhim JS, Macoska JA (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors". Cancer Res. 61 (6): 2390–4. PMID11289102.
Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID12370826.
Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells". Int. J. Biochem. Cell Biol. 38 (5–6): 1015–22. doi:10.1016/j.biocel.2005.11.012. PMID16413998.
