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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Osler node is a characteristic of subacute bacterial endocarditis. It is small, papulopustular/nodular & tender cutaneus lesion. There is controversy about the exact origin of the lesion.

Differential Diagnosis

In alphabetical order. [1] [2]


Physical examination


  • New murmer may suggest infective endocarditis

Laboratory Findings

  • Labs include:
  • TTP - schistocytes on blood smear, increased LDH & indirect bilirubin
  • ITP - platelet-associated IgG test

Chest X Ray

  • X-ray for septic emboli

Echocardiography or Ultrasound


Acute Pharmacotherapies

Chronic Pharmacotherapies

Indications for Surgery

  • Bacterial endocarditis - valve replacement (subjective)


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X