ORC1L

Origin recognition complex, subunit 1-like (yeast)
Identifiers
Symbols	ORC1L ; HSORC1; ORC1; PARC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31221
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ORC1L 205085 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Origin recognition complex, subunit 1-like (yeast), also known as ORC1L, is a human gene.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.

Further reading

• Gavin KA, Hidaka M, Stillman B (1996). "Conserved initiator proteins in eukaryotes". Science. 270 (5242): 1667–71. PMID 7502077.CS1 maint: Multiple names: authors list (link)
• Eki T, Okumura K, Amin A; et al. (1997). "Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32". Genomics. 36 (3): 559–61. doi:10.1006/geno.1996.0511. PMID 8884289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohtani K, DeGregori J, Leone G; et al. (1997). "Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor". Mol. Cell. Biol. 16 (12): 6977–84. PMID 8943353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saha P, Chen J, Thome KC; et al. (1998). "Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase". Mol. Cell. Biol. 18 (5): 2758–67. PMID 9566895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iizuka M, Stillman B (1999). "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein". J. Biol. Chem. 274 (33): 23027–34. PMID 10438470.
• Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMID 10523313.CS1 maint: Multiple names: authors list (link)
• Tatsumi Y, Tsurimoto T, Shirahige K; et al. (2000). "Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures". J. Biol. Chem. 275 (8): 5904–10. PMID 10681582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thome KC, Dhar SK, Quintana DG; et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". J. Biol. Chem. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex". J. Biol. Chem. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.CS1 maint: Multiple names: authors list (link)
• Laman H, Peters G, Jones N (2002). "Cyclin-mediated export of human Orc1". Exp. Cell Res. 271 (2): 230–7. doi:10.1006/excr.2001.5360. PMID 11716535.CS1 maint: Multiple names: authors list (link)
• Fujita M, Ishimi Y, Nakamura H; et al. (2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ladenburger EM, Keller C, Knippers R (2002). "Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication". Mol. Cell. Biol. 22 (4): 1036–48. PMID 11809796.CS1 maint: Multiple names: authors list (link)
• Méndez J, Zou-Yang XH, Kim SY; et al. (2002). "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Mol. Cell. 9 (3): 481–91. PMID 11931757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. PMID 12614612.CS1 maint: Multiple names: authors list (link)
• Ohta S, Tatsumi Y, Fujita M; et al. (2003). "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle". J. Biol. Chem. 278 (42): 41535–40. doi:10.1074/jbc.M307535200. PMID 12909626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatsumi Y, Ohta S, Kimura H; et al. (2003). "The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1". J. Biol. Chem. 278 (42): 41528–34. doi:10.1074/jbc.M307534200. PMID 12909627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdurashidova G, Danailov MB, Ochem A; et al. (2003). "Localization of proteins bound to a replication origin of human DNA along the cell cycle". EMBO J. 22 (16): 4294–303. doi:10.1093/emboj/cdg404. PMID 12912926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramachandran N, Hainsworth E, Bhullar B; et al. (2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lidonnici MR, Rossi R, Paixão S; et al. (2005). "Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle". J. Cell. Sci. 117 (Pt 22): 5221–31. doi:10.1242/jcs.01405. PMID 15454574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)