Nocturnal asthma overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Nocturnal asthma is defined by a drop in forced expiratory volume in 1 second (FEV1) of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of asthma.[1] The pathophysiology of nocturnal asthma is closely associated with the chronobiology and the science of biologic processes that have time-related rhythms. Hence, understanding the circadian rhythm is important to interpret the changes in pulmonary function that occurs in sleeping asthmatics. A large population based study reported dyspneic episodes without therapy in asthmatics occurred between 10 P.M. and 7 A.M.[2] Another population based survey that assessed 7729 patients, reported approximate 74% patients woke-up at least once a week with symptoms, 64% woke-up three times per week, and 39% patients woke-up every night with symptoms.[3]
Epidemiology and Demographics
Nocturnal worsening of asthma is very common clinical finding in asthmatics affecting approximately 75% of asthmatics who awaken at least once per week because of symptoms, and approximately 40% experience nocturnal symptoms on a nightly basis.[1][4]
References
- ↑ 1.0 1.1 Sutherland ER (2005) Nocturnal asthma: underlying mechanisms and treatment. Curr Allergy Asthma Rep 5 (2):161-7. PMID: 15683618
- ↑ Martin RJ (1993) Nocturnal asthma: circadian rhythms and therapeutic interventions. Am Rev Respir Dis 147 (6 Pt 2):S25-8. PMID: 8494197
- ↑ Turner-Warwick M (1988) Epidemiology of nocturnal asthma. Am J Med 85 (1B):6-8. PMID: 3400687
- ↑ Sutherland ER (2005) Nocturnal asthma. J Allergy Clin Immunol 116 (6):1179-86; quiz 1187. DOI:10.1016/j.jaci.2005.09.028 PMID: 16337443