No-reflow phenomenon historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jennifer Giuseffi, M.D.; David M. Leder, M.D.; Ayokunle Olubaniyi, M.B,B.S [2]

Overview

This phenomenon was first described by Krug et al [1] during induced myocardial infarction in dog subjects in 1966, but the term 'no-reflow' was first used by Majno and colleagues in 1967 when they observed that brains of rabbits exposed to prolonged ischemia suffered significant changes in the microvasculature which impeded blood flow to the brain cells.

References

  1. Krug, A.; Du Mesnil de Rochemont, G.; Korb, . (1966). "Blood supply of the myocardium after temporary coronary occlusion.". Circ Res. 19 (1): 57–62. PMID 5912914. 

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