NK1 receptor antagonist

Jump to: navigation, search

Neurokinin NK1 antagonists are a novel class of medications that possesses unique antidepressant[1], anxiolytic[2], and antiemetic properties.

The NK2 and NK3 receptors are also targets for novel classes of medications, and also show prominent antidepressive and anxiolytic effects.[3]

See also


  1. Varty GB, Cohen-Williams ME, Hunter JC (2003). "The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test". Behavioural pharmacology. 14 (1): 87–95. doi:10.1097/01.fbp.0000055962.09493.e9. PMID 12576885.
  2. Varty GB, Cohen-Williams ME, Morgan CA; et al. (2002). "The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists". Neuropsychopharmacology. 27 (3): 371–9. doi:10.1016/S0893-133X(02)00313-5. PMID 12225694.
  3. Salomé N, Stemmelin J, Cohen C, Griebel G (2006). "Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils". Pharmacol. Biochem. Behav. 83 (4): 533–9. doi:10.1016/j.pbb.2006.03.013. PMID 16624395.