NFAM1 (gene)

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene.

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

Further reading

• Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi:10.1074/jbc.M211060200. PMID 12615919.
• Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation". Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi:10.1152/ajpcell.00590.2005. PMID 17079331.
• Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi:10.1016/j.virol.2007.10.029. PMC 2289909. PMID 18031784.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.