Mitral valve prolapse causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Farman Khan, MD, MRCP [2]

Overview

Mitral valve prolapse (MVP) is a valvular heart disease that is considered to be mainly hereditary. Myxomatous degeneration of the mitral valve is a common cause of MVP. Other less common causes of MVP include connective tissue diseases such as Marfan's syndrome, Ehlers Danlos syndrome and osteogenesis imperfecta, as well as damage to the mitral valve secondary to infarction, rheumatic heart disease, hypertrophic cardiomyopathy and trauma.

Causes

Common Causes

Causes by Organ System

Cardiovascular myxomatous of the mitral valve, myocardial infarction, severe mitral annular calcification, damaged chordae tendineae, rheumatic heart disease, papillary muscle dysfunction, hypertrophic cardiomyopathy, forme fruste Barlow disease, Ebstein's anomaly , cardiomegaly, bacterial endocarditis, congenital heart disease
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine Graves disease
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Turner Syndrome, spastic ataxia, Charlevoix-Saguenay type, osteogenesis imperfecta, X-linked familial mitral valve prolapse, autosomal dominant familial mitral valve prolapse, MASS phenotype, Marfan syndrome, Marfan-like syndrome Boileau type, Hunter-Mcdonald syndrome, Furlong-Kurczynski-Hennessy syndrome
Hematologic Von Willebrand disease, sickle cell disease
Iatrogenic No underlying causes
Infectious Disease Infective endocarditis, acute rheumatic fever
Musculoskeletal/Orthopedic Dermato-cardio-skeletal syndrome Borrone type
Neurologic No underlying causes
Nutritional/Metabolic Scurvy
Obstetric/Gynecologic Pregnancy
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Polycystic kidney disease
Rheumatology/Immunology/Allergy SLE, pseudoxanthoma elasticum, polyarteritis nodosa, connective tissue disease, mixed connective tissue disease, Ehlers-Danlos syndrome type I, Ehlers-Danlos syndrome type II, Ehlers-Danlos syndrome Type V
Sexual No underlying causes
Trauma Trauma to mitral valve
Urologic No underlying causes
Miscellaneous Stickler Syndrome, Leopard syndrome, idiopathic, fibroelastic deficiency, Dahlberg syndrome, Beals syndrome

Causes in Alphabetical Order

References

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