Minimal lesion syndrome

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List of terms related to Minimal lesion syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Minimal residual coronary obstruction

Minimal Lesion Syndrome

After initiation of thrombolytic therapy for patients with acute myocardial infarction, minimal lesion syndrome is defined as the presence of an insignificant (≤50%) residual coronary obstruction of infarct-related artery vessel on coronary angiography. Despite insignificant reduction in the lumen diameter, in situ thrombosis or minimal intimal irregularities is usually present. Coronary vasospasm with subsequent thrombus formation overlying a minimally encroaching atherosclerotic plaque is implicated in the pathogenesis for minimal lesion syndrome, and these patients are typically young male and heavy smokers. Smoking cessation and empirical use of nitrates or calcium channel blockers are required. In light of the unfavorable prognosis in a subset of these patients, longer follow-up may be needed to determine the risk for rethrombosis events.

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