Milk-alkali syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]

Overview

The following laboratory findings are usually seen in milk-alkali syndrome: hypercalcemia, metabolic alkalosis, variable degrees of renal insufficiency, low or normal phosphorus, low Vitamin D, and low PTH.

Laboratory Findings

• The following laboratory findings are seen in milk-alkali syndrome:
  • Hypercalcemia
  • Metabolic alkalosis
    • Increase in bicarbonate and alkalotic pH  
  • Variable degrees of renal insufficiency  
  • Phosphorus may be normal or low
    • Phosphorus levels used to be high in the classic milk-alkali syndrome due to the high phosphorus load from cream and milk consumption and renal insufficiency
  • Vitamin D is usually low
  • Parathyroid hormone (PTH) is usually low
    • PTH should be checked in order to rule out primary hyperparathyroidism.