Mental disorder risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Risk factors for mental disorder include brain malformation, hypoxic ischemic injury, and infections among others.

Risk Factors

Prenatal Factors

• Inborn errors of metabolism
• Brain malformations
• Maternal disease (including placental disease)
• Environmental influences (e.g., alcohol, other drugs, toxins, teratogens)

Perinatal Factors

• Neonatal encephalopathy

Postnatal Factors

• Hypoxic ischemic injury
• Traumatic brain injury
• Infections
• Demyelinating disorders
• Seizure disorders (e.g., infantile spasms)
• Severe and chronic social deprivation
• Toxic metabolic syndromes and intoxications (e.g., lead, mercury)