Melanosis coli

Jump to navigation Jump to search


Overview

WikiDoc Resources for Melanosis coli

Articles

Most recent articles on Melanosis coli

Most cited articles on Melanosis coli

Review articles on Melanosis coli

Articles on Melanosis coli in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Melanosis coli

Images of Melanosis coli

Photos of Melanosis coli

Podcasts & MP3s on Melanosis coli

Videos on Melanosis coli

Evidence Based Medicine

Cochrane Collaboration on Melanosis coli

Bandolier on Melanosis coli

TRIP on Melanosis coli

Clinical Trials

Ongoing Trials on Melanosis coli at Clinical Trials.gov

Trial results on Melanosis coli

Clinical Trials on Melanosis coli at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Melanosis coli

NICE Guidance on Melanosis coli

NHS PRODIGY Guidance

FDA on Melanosis coli

CDC on Melanosis coli

Books

Books on Melanosis coli

News

Melanosis coli in the news

Be alerted to news on Melanosis coli

News trends on Melanosis coli

Commentary

Blogs on Melanosis coli

Definitions

Definitions of Melanosis coli

Patient Resources / Community

Patient resources on Melanosis coli

Discussion groups on Melanosis coli

Patient Handouts on Melanosis coli

Directions to Hospitals Treating Melanosis coli

Risk calculators and risk factors for Melanosis coli

Healthcare Provider Resources

Symptoms of Melanosis coli

Causes & Risk Factors for Melanosis coli

Diagnostic studies for Melanosis coli

Treatment of Melanosis coli

Continuing Medical Education (CME)

CME Programs on Melanosis coli

International

Melanosis coli en Espanol

Melanosis coli en Francais

Business

Melanosis coli in the Marketplace

Patents on Melanosis coli

Experimental / Informatics

List of terms related to Melanosis coli

Melanosis coli identified on colonoscopy as a brownish moire pattern on the wall of the colon.

Melanosis coli is a disorder of pigmentation of the wall of the colon, identified at the time of colonoscopy. It is benign, and has no significant correlation with disease. The name is considered a misnomer: the brown pigment seen in the colon is actually lipofuscin, not melanin as the name implies.

The most common cause of melanosis coli is the surreptitious use of laxatives, and commonly anthraquinone containing laxatives such as Senna and other plant glycosides. [1] Endoscopically, the mucosa shows a brownish discoloration in a moire pattern. On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the submucosa on PAS staining.[2]

No adverse effects or consequences of melanosis coli have been identified.[2] The condition is unrelated to Peutz-Jeghers syndrome, which can cause pigmentation of the skin and mucous surfaces with melanin, and polyps in the digestive tract.

Melanoses of other parts of the gastrointestinal tract have also been reported, and are of unclear relevance.[3] Patients with colostomies can have melanosis involving the stoma, which is also of no significance.[4]

H & E stain of colon biopsy showing melanosis coli, which appears as brown pigmentation in the macrophages in the lamina propria.











See also

References

  1. Muller-Lissner SA. Adverse effects of laxatives: fact and fiction. Pharmacology. 1993 Oct;47 Suppl 1:138-45. PMID 8234421
  2. 2.0 2.1 Wittoesch JH, Jackman RJ, McDonald JR. Melanosis coli: general review and a study of 887 cases. Dis Colon Rectum. 1958 May-Jun;1(3):172-80. PMID 13537819.
  3. Ghadially FN, Walley VM. Melanoses of the gastrointestinal tract. Histopathology. 1994 Sep;25(3):197-207. PMID 7821887
  4. Fleischer I, Bryant D. Melanosis coli or mucosa ischemia? A case report. Ostomy Wound Manage. 1995 May;41(4):44, 46-7. PMID 7598783

External links

de:Melanosis coli

Template:WH Template:WikiDoc Sources