Mef2c

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MEF2C (Myocyte enhancer factor 2C) is a transcription factor in the Mef2 family.[1] The Mef2c gene is necessary for proper embryonic development: mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.[2]


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References

  1. Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C". Mol Cell Biol. 16 (6): 2627–36. PMID 8649370.
  2. Bi W, Drake CJ, Schwarz JJ (1999). "The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF". Developmental Biology. 211 (2): 255–67. PMID 10395786.



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