Medical Hypotheses is a monthly journal published by Elsevier. It began in 1975.
Medical Hypotheses provides a forum for unconventional ideas in medicine. The papers do not have to go through the peer review process. The editors choose which article to publish on the basis of interest and importance in order to foster debate.
The journal was founded by David Horrobin. The original Editorial Board comprised: the double Nobel Laureate Linus Pauling, the Nobel Laureate Sir Macfarlane Burnet, the philosopher Sir Karl Popper, the Nobel Laureate in physiology Sir John Eccles and the acclaimed physiologist Arthur Guyton. Among others its present board includes Antonio Damasio and the Nobel Laureate Arvid Carlsson, and it remains the only journal format venue for pure medical and biomedical theory in the world.