Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described.[3]
References
↑Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem. 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID11121398.
↑Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID11255011.
Illman SA, Keski-Oja J, Lohi J (2001). "Promoter characterization of the human and mouse epilysin (MMP-28) genes". Gene. 275 (1): 185–94. doi:10.1016/S0378-1119(01)00664-3. PMID11574168.
Saarialho-Kere U, Kerkelä E, Jahkola T, et al. (2002). "Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair". J. Invest. Dermatol. 119 (1): 14–21. doi:10.1046/j.1523-1747.2002.01790.x. PMID12164918.
Bar-Or A, Nuttall RK, Duddy M, et al. (2003). "Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis". Brain. 126 (Pt 12): 2738–49. doi:10.1093/brain/awg285. PMID14506071.
Kevorkian L, Young DA, Darrah C, et al. (2004). "Expression profiling of metalloproteinases and their inhibitors in cartilage". Arthritis Rheum. 50 (1): 131–41. doi:10.1002/art.11433. PMID14730609.
Bister VO, Salmela MT, Karjalainen-Lindsberg ML, et al. (2004). "Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer". Dig. Dis. Sci. 49 (4): 653–61. doi:10.1023/B:DDAS.0000026314.12474.17. PMID15185874.
Momohara S, Okamoto H, Komiya K, et al. (2005). "Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al". Arthritis Rheum. 50 (12): 4074–5, author reply 4075. doi:10.1002/art.20799. PMID15593191.
Renò F, Sabbatini M, Stella M, et al. (2005). "Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars". Wound Repair and Regeneration. 13 (3): 255–61. doi:10.1111/j.1067-1927.2005.130307.x. PMID15953044.
External links
The MEROPS online database for peptidases and their inhibitors: M10.030
