MAP1B

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A and RASSF1.

Further reading

• Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron. 7 (1): 129–39. doi:10.1016/0896-6273(91)90081-A. PMID 1712602.
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
• Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. doi:10.1006/cbir.1994.1079. PMID 7519512.
• Lien LL, Feener CA, Fischbach N, Kunkel LM (1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
• Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. doi:10.1016/S0387-7604(97)00088-0. PMID 9533556.
• Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell Sci. 111 ( Pt 10) (10): 1351–61. PMID 9570753.
• Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. doi:10.1083/jcb.143.3.695. PMC 2148156. PMID 9813091.
• Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.
• Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.
• Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. doi:10.1046/j.1471-4159.2000.0750553.x. PMID 10899930.
• Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287.
• Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
• Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH (2001). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMC 2150906. PMID 11733546.
• Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMC 2173828. PMID 12147674.
• Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2003). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. doi:10.1016/S1389-0344(03)00003-0. PMID 12684070.
• Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell. 4 (4): 521–33. doi:10.1016/S1534-5807(03)00094-7. PMID 12689591.
• Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.