Lon peptidase 2, peroxisomal

Jump to navigation Jump to search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lon peptidase 2, peroxisomal is a protein that in humans is encoded by the LONP2 gene. [1]

Function

In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].

References

  1. "Entrez Gene: Lon peptidase 2, peroxisomal". Retrieved 2017-12-04.

Further reading

  • Ondrovicová G, Liu T, Singh K, Tian B, Li H, Gakh O, Perecko D, Janata J, Granot Z, Orly J, Kutejová E, Suzuki CK (2005). "Cleavage site selection within a folded substrate by the ATP-dependent lon protease". J. Biol. Chem. 280 (26): 25103–10. doi:10.1074/jbc.M502796200. PMID 15870080.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.