Levoverbenone

	WikiDoc Resources for Levoverbenone
Articles
Most recent articles on Levoverbenone Most cited articles on Levoverbenone Review articles on Levoverbenone Articles on Levoverbenone in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Levoverbenone Images of Levoverbenone Photos of Levoverbenone Podcasts & MP3s on Levoverbenone Videos on Levoverbenone
Evidence Based Medicine
Cochrane Collaboration on Levoverbenone Bandolier on Levoverbenone TRIP on Levoverbenone
Clinical Trials
Ongoing Trials on Levoverbenone at Clinical Trials.gov Trial results on Levoverbenone Clinical Trials on Levoverbenone at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Levoverbenone NICE Guidance on Levoverbenone NHS PRODIGY Guidance FDA on Levoverbenone CDC on Levoverbenone
Books
Books on Levoverbenone
News
Levoverbenone in the news Be alerted to news on Levoverbenone News trends on Levoverbenone
Commentary
Blogs on Levoverbenone
Definitions
Definitions of Levoverbenone
Patient Resources / Community
Patient resources on Levoverbenone Discussion groups on Levoverbenone Patient Handouts on Levoverbenone Directions to Hospitals Treating Levoverbenone Risk calculators and risk factors for Levoverbenone
Healthcare Provider Resources
Symptoms of Levoverbenone Causes & Risk Factors for Levoverbenone Diagnostic studies for Levoverbenone Treatment of Levoverbenone
Continuing Medical Education (CME)
CME Programs on Levoverbenone
International
Levoverbenone en Espanol Levoverbenone en Francais
Business
Levoverbenone in the Marketplace Patents on Levoverbenone
Experimental / Informatics
List of terms related to Levoverbenone

Levoverbenone
Clinical data
ATC code	R05CA11 (WHO) ;
Identifiers
	IUPAC name (1S,5R)-4,6,6-trimethylbicyclo[3.1.1]hept-3-en-2-one;
CAS Number	1196-01-6 ;
PubChem CID	92874;
ChemSpider	83838 ;
UNII	2XP0J7754U;
ChEBI	CHEBI:78316 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H14O
Molar mass	150.218 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1\C=C(/[C@@H]2C[C@H]1C2(C)C)C;
	InChI InChI=1S/C10H14O/c1-6-4-9(11)8-5-7(6)10(8,2)3/h4,7-8H,5H2,1-3H3/t7-,8+/m0/s1 ; Key:DCSCXTJOXBUFGB-JGVFFNPUSA-N ;
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Levoverbenone is an expectorant. It is the L-isomer of verbenone.

Use of Levoverbenone for insect control

The southern pine beetle (Dendroctonus frontalis), a bark beetle, is a major threat to pine trees in the southeastern United States. Its reproductive cycle is controlled by varying ratios of certain natural chemicals, including verbenone. To reproduce, pine bark beetles aggregate in large numbers in their host pine trees. At the beginning of an attack, various chemicals produced by infested trees and by the beetles attract additional beetles of the same species. When the numbers of adults and larvae approach the maximum that the tree can support, antiaggregation signal chemicals, i.e., verbenone, are produced, reducing the likelihood that additional beetles will land and attack the tree. Forest managers frequently try to control infestations of the Southern pine bark beetle by cutting down and sometimes burning infested trees and nearby healthy trees. They then place verbenone formulations on nearby susceptible healthy trees to repel and confuse the beetles.^[1]

Levoverbenone or (-)Verbenone is also used to manage mountain pine beetle (Dendroctonus ponderosae) infestations.^[2] Verbenone is the principal antiaggregation pheromone of the mountain pine beetle, Dendroctonus ponderosae Hopkins, a notable forest insect capable of causing extensive levels of tree mortality in western North America. Although several formulations of verbenone have been registered with the U.S. Environmental Protection Agency ^[3] for tree protection, failures in efficacy are rather common. Unlike previous formulations, a new formulation of (–)-verbenone registered as SPLAT® Verb ^[4] (ISCA Technologies Inc., Riverside, CA) was found to be extremely efficient in protecting individual lodgepole pine, Pinus contorta Dougl. ex Loud., and small stands of P. contorta from mortality attributed to D. ponderosae. SPLAT® Verb applications resulted in complete individual P. contorta tree protection while 93.3% mortality occurred in the untreated controls; furthermore significantly fewer P. contorta were killed by D. ponderosae within 0.041-ha circular plots (11-m radius) surrounding P. contorta treated with SPLAT® Verb compared to the untreated control.^[5]

References

↑ U.S. Environmental Protection Agency Pesticide Fact Sheet #128986.
↑ Mafra-Neto, Agenor; de Lame, Frédérique M.; Fettig, Christopher J.; Perring, Thomas M.; Stelinski, Lukasz L.; Stoltman, Lyndsie L.; Mafra, Leandro E. J.; Borges, Rafael; Vargas, Roger I. (2013). "Manipulation of Insect Behavior with Specialized Pheromone and Lure Application Technology (SPLAT®)". In John Beck, Joel Coats, Stephen Duke, and Marja Koivunen. Natural Products for Pest Management. 1141. American Chemical Society. pp. 31–58.
↑ U.S. Environmental Protection Agency Pesticide Fact Sheet #128986.
↑ SPLAT Verb Information Page http://www.iscatech.com/exec/SPLATVerbtest.html
↑ Mafra-Neto, Agenor; Fettig, Christopher J.; Munson, A.S.; Stelinski, Lukasz L. (2014). "The use of repellents formulated in Specialized Pheromone and Lure Application Technology (SPLAT®) for effective insect pest management.". In Debboun, M., S.P. Francis, and D.A. Strickman. Insect Repellents Handbook, Second Edition. Taylor & Francis, London. pp. 291–314.

Template:Cough and cold preparations

[1] U.S. Environmental Protection Agency Pesticide Fact Sheet #128986.

[2] Mafra-Neto, Agenor; de Lame, Frédérique M.; Fettig, Christopher J.; Perring, Thomas M.; Stelinski, Lukasz L.; Stoltman, Lyndsie L.; Mafra, Leandro E. J.; Borges, Rafael; Vargas, Roger I. (2013). "Manipulation of Insect Behavior with Specialized Pheromone and Lure Application Technology (SPLAT®)". In John Beck, Joel Coats, Stephen Duke, and Marja Koivunen. Natural Products for Pest Management. 1141. American Chemical Society. pp. 31–58.

[3] U.S. Environmental Protection Agency Pesticide Fact Sheet #128986.

[4] SPLAT Verb Information Page http://www.iscatech.com/exec/SPLATVerbtest.html

[5] Mafra-Neto, Agenor; Fettig, Christopher J.; Munson, A.S.; Stelinski, Lukasz L. (2014). "The use of repellents formulated in Specialized Pheromone and Lure Application Technology (SPLAT®) for effective insect pest management.". In Debboun, M., S.P. Francis, and D.A. Strickman. Insect Repellents Handbook, Second Edition. Taylor & Francis, London. pp. 291–314.

[1]

[2]

[3]

[4]

[5]

Clinical data

ATC code	R05CA11 (WHO)
Identifiers
IUPAC name (1S,5R)-4,6,6-trimethylbicyclo[3.1.1]hept-3-en-2-one
CAS Number	1196-01-6^Y
PubChem CID	92874
ChemSpider	83838^Y
UNII	2XP0J7754U
ChEBI	CHEBI:78316^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₀H₁₄O
Molar mass	150.218 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1\C=C(/[C@@H]2C[C@H]1C2(C)C)C
InChI InChI=1S/C10H14O/c1-6-4-9(11)8-5-7(6)10(8,2)3/h4,7-8H,5H2,1-3H3/t7-,8+/m0/s1^Y Key:DCSCXTJOXBUFGB-JGVFFNPUSA-N^Y
^NY (what is this?) (verify)

Levoverbenone

Overview

Use of Levoverbenone for insect control

References

Navigation menu