LRAT

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Identifiers
Symbols	LRAT ; MGC33103
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3483
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LRAT 220317 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), also known as LRAT, is a human gene.

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Further reading

• Ross AC, Zolfaghari R (2004). "Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status". J. Nutr. 134 (1): 269S–275S. PMID 14704332.
• Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. PMID 1322170.
• Mata NL, Tsin AT (1998). "Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes". Biochim. Biophys. Acta. 1394 (1): 16–22. PMID 9767084.
• Ruiz A, Winston A, Lim YH; et al. (1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J. Biol. Chem. 274 (6): 3834–41. PMID 9920938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mondal MS, Ruiz A, Bok D, Rando RR (2000). "Lecithin retinol acyltransferase contains cysteine residues essential for catalysis". Biochemistry. 39 (17): 5215–20. PMID 10819989.CS1 maint: Multiple names: authors list (link)
• Ruiz A, Kuehn MH, Andorf JL; et al. (2001). "Genomic organization and mutation analysis of the gene encoding lecithin retinol acyltransferase in human retinal pigment epithelium". Invest. Ophthalmol. Vis. Sci. 42 (1): 31–7. PMID 11133845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andreola F, Giandomenico V, Spero R, De Luca LM (2001). "Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells". Biochem. Biophys. Res. Commun. 279 (3): 920–4. doi:10.1006/bbrc.2000.3995. PMID 11162450.CS1 maint: Multiple names: authors list (link)
• Thompson DA, Li Y, McHenry CL; et al. (2001). "Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy". Nat. Genet. 28 (2): 123–4. doi:10.1038/88828. PMID 11381255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jahng WJ, Cheung E, Rando RR (2002). "Lecithin retinol acyltransferase forms functional homodimers". Biochemistry. 41 (20): 6311–9. PMID 12009892.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhan HC, Gudas LJ, Bok D; et al. (2004). "Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney". Clin. Cancer Res. 9 (13): 4897–905. PMID 14581364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jahng WJ, Xue L, Rando RR (2004). "Lecithin retinol acyltransferase is a founder member of a novel family of enzymes". Biochemistry. 42 (44): 12805–12. doi:10.1021/bi035370p. PMID 14596594.CS1 maint: Multiple names: authors list (link)
• Boorjian S, Tickoo SK, Mongan NP; et al. (2004). "Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer". Clin. Cancer Res. 10 (10): 3429–37. doi:10.1158/1078-0432.CCR-03-0756. PMID 15161698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zolfaghari R, Ross AC (2005). "Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver". Gene. 341: 181–8. doi:10.1016/j.gene.2004.06.043. PMID 15474300.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Byrne SM, Wongsiriroj N, Libien J; et al. (2005). "Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)". J. Biol. Chem. 280 (42): 35647–57. doi:10.1074/jbc.M507924200. PMID 16115871.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xue L, Jahng WJ, Gollapalli D, Rando RR (2006). "Palmitoyl transferase activity of lecithin retinol acyl transferase". Biochemistry. 45 (35): 10710–8. doi:10.1021/bi060897y. PMID 16939223.CS1 maint: Multiple names: authors list (link)
• Sénéchal A, Humbert G, Surget MO; et al. (2006). "Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis". Am. J. Ophthalmol. 142 (4): 702–4. doi:10.1016/j.ajo.2006.04.057. PMID 17011878.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)