Kindler syndrome

Jump to: navigation, search

WikiDoc Resources for Kindler syndrome

Articles

Most recent articles on Kindler syndrome

Most cited articles on Kindler syndrome

Review articles on Kindler syndrome

Articles on Kindler syndrome in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Kindler syndrome

Images of Kindler syndrome

Photos of Kindler syndrome

Podcasts & MP3s on Kindler syndrome

Videos on Kindler syndrome

Evidence Based Medicine

Cochrane Collaboration on Kindler syndrome

Bandolier on Kindler syndrome

TRIP on Kindler syndrome

Clinical Trials

Ongoing Trials on Kindler syndrome at Clinical Trials.gov

Trial results on Kindler syndrome

Clinical Trials on Kindler syndrome at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Kindler syndrome

NICE Guidance on Kindler syndrome

NHS PRODIGY Guidance

FDA on Kindler syndrome

CDC on Kindler syndrome

Books

Books on Kindler syndrome

News

Kindler syndrome in the news

Be alerted to news on Kindler syndrome

News trends on Kindler syndrome

Commentary

Blogs on Kindler syndrome

Definitions

Definitions of Kindler syndrome

Patient Resources / Community

Patient resources on Kindler syndrome

Discussion groups on Kindler syndrome

Patient Handouts on Kindler syndrome

Directions to Hospitals Treating Kindler syndrome

Risk calculators and risk factors for Kindler syndrome

Healthcare Provider Resources

Symptoms of Kindler syndrome

Causes & Risk Factors for Kindler syndrome

Diagnostic studies for Kindler syndrome

Treatment of Kindler syndrome

Continuing Medical Education (CME)

CME Programs on Kindler syndrome

International

Kindler syndrome en Espanol

Kindler syndrome en Francais

Business

Kindler syndrome in the Marketplace

Patents on Kindler syndrome

Experimental / Informatics

List of terms related to Kindler syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Kindler syndrome (also known as "Bullous acrokeratotic poikiloderma of Kindler and Weary, "Congenital poikiloderma with blisters and keratosis,"Congenital poikiloderma with bullae and progressive cutaneous atrophy,"Hereditary acrokeratotic poikiloderma, "Hyperkeratosis–hyperpigmentation syndrome,"Acrokeratotic poikiloderma," and "Weary–Kindler syndrome,Andrews' Diseases of the Skin) is a rare congenital disease of the skin caused by a mutation in the KIND1 gene. Infants and young children with Kindler syndrome have a tendency to blister with minor trauma and are prone to sunburns. As individuals with Kindler syndrome age, they tend to have fewer problems with blistering and photosensitivity. However, pigment changes and thinning of the skin become more prominent.

Kindler syndrome is an autosomal recessive genodermatosis. The KIND1 gene mutated in Kindler syndrome codes for the protein kindlin-1, which is thought to be active in the interactions between actin and the extracellular matrix.[1] Kindler syndrome was first described in 1954 by Theresa Kindler.[2]

References

  1. Siegel DH, Ashton GH, Penagos HG, Lee JV, Feiler HS, Wilhelmsen KC, South AP, Smith FJ, Prescott AR, Wessagowit V, Oyama N, Akiyama M, Al Aboud D, Al Aboud K, Al Githami A, Al Hawsawi K, Al Ismaily A, Al-Suwaid R, Atherton DJ, Caputo R, Fine JD, Frieden IJ, Fuchs E, Haber RM, Harada T, Kitajima Y, Mallory SB, Ogawa H, Sahin S, Shimizu H, Suga Y, Tadini G, Tsuchiya K, Wiebe CB, Wojnarowska F, Zaghloul AB, Hamada T, Mallipeddi R, Eady RA, McLean WH, McGrath JA, Epstein EH. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet. 2003 Jul;73(1):174-87. Epub 2003 Jun 3. PMID 12789646
  2. Kindler, T. Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy. Br J Dermatol. 1954 Mar;66(3):104-11. No abstract available. PMID 13149722



Linked-in.jpg