Ipratropium overdose

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Acute systemic over dosage by inhalation is unlikely since Ipratropium bromide is not well absorbed after inhalation at up to four-fold the recommended dose, or after oral administration at up to forty-fold the recommended dose. The oral LD50 of Ipratropium bromide ranged between 1001 and 2010 mg/kg in mice; between 1667 and 4000 mg/kg in rats; and between 400 and 1300 mg/kg in dogs.

Adapted from the FDA Package Insert.