Iopanoic acid

Jump to: navigation, search
Iopanoic acid
Iopanoic acid Wiki Str.png
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass570.93 g/mol
3D model (JSmol)

WikiDoc Resources for Iopanoic acid


Most recent articles on Iopanoic acid

Most cited articles on Iopanoic acid

Review articles on Iopanoic acid

Articles on Iopanoic acid in N Eng J Med, Lancet, BMJ


Powerpoint slides on Iopanoic acid

Images of Iopanoic acid

Photos of Iopanoic acid

Podcasts & MP3s on Iopanoic acid

Videos on Iopanoic acid

Evidence Based Medicine

Cochrane Collaboration on Iopanoic acid

Bandolier on Iopanoic acid

TRIP on Iopanoic acid

Clinical Trials

Ongoing Trials on Iopanoic acid at Clinical

Trial results on Iopanoic acid

Clinical Trials on Iopanoic acid at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Iopanoic acid

NICE Guidance on Iopanoic acid


FDA on Iopanoic acid

CDC on Iopanoic acid


Books on Iopanoic acid


Iopanoic acid in the news

Be alerted to news on Iopanoic acid

News trends on Iopanoic acid


Blogs on Iopanoic acid


Definitions of Iopanoic acid

Patient Resources / Community

Patient resources on Iopanoic acid

Discussion groups on Iopanoic acid

Patient Handouts on Iopanoic acid

Directions to Hospitals Treating Iopanoic acid

Risk calculators and risk factors for Iopanoic acid

Healthcare Provider Resources

Symptoms of Iopanoic acid

Causes & Risk Factors for Iopanoic acid

Diagnostic studies for Iopanoic acid

Treatment of Iopanoic acid

Continuing Medical Education (CME)

CME Programs on Iopanoic acid


Iopanoic acid en Espanol

Iopanoic acid en Francais


Iopanoic acid in the Marketplace

Patents on Iopanoic acid

Experimental / Informatics

List of terms related to Iopanoic acid

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism, particularly when they are used as an adjunctive therapy with thioamides (propylthiouracil, carbimazole). These are less toxic, as iodine is covalently bound in these compounds. They can be used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction, or stroke) for rapid control of elevated plasma triiodothyronine concentrations. The use of iopanoic acid for treatment of thyrotoxicosis has been discontinued in the United States.

In addition to inhibiting deiodinase enzymes, iopanoic acid is also a substrate of type 1 deiodinase. Iopanoic acid underwent monodeiodination in the presence of type 1 deiodinase in a microsomal mouse liver preparation.[1]


  1. Renko, K.; Hoefig, C. S.; Hiller, F.; Schomburg, L.; Kohrle, J. (20 March 2012). "Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay". Endocrinology. 153 (5): 2506–2513. doi:10.1210/en.2011-1863.