Initiator motif

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The Initiatior (Inr) motif is a DNA transcription promoter that is similar in function to the Pribnow box (for prokaryotes) or the TATA box (for eukaryotes). It has the consensus sequence YYAN(T/A)YY,[1] where Y stands for any pyrimidine (cytosine or thymine). Similarly to the TATA box, the Inr motif facilitates the binding of Transcription Factor II D (TBP).[1]


  1. 1.0 1.1 Xi, Hualin (June 2007). "Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1". Genome Research. 17 (6): 798–806. ISSN 1088-9051. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)