Importin 8 is a protein that in humans is encoded by the IPO8 gene.[1]
Function
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Dean KA, von Ahsen O, Görlich D, Fried HM (October 2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". Journal of Cell Science. 114 (Pt 19): 3479–85. PMID11682607.
Weinmann L, Höck J, Ivacevic T, Ohrt T, Mütze J, Schwille P, Kremmer E, Benes V, Urlaub H, Meister G (February 2009). "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs". Cell. 136 (3): 496–507. doi:10.1016/j.cell.2008.12.023. PMID19167051.
Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, Chen X (July 2010). "14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity". Journal of Proteome Research. 9 (7): 3465–78. doi:10.1021/pr9011377. PMID20462248.
