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Interferon, alpha 1
Symbols IFNA1 ; IFL; IFN; IFN-ALPHA; IFNA13; IFNA@; MGC138207; MGC138505; MGC138507
External IDs Template:OMIM5 HomoloGene88748
RNA expression pattern
PBB GE IFNA1 208344 x at tn.png
PBB GE IFNA1 208375 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Interferon, alpha 1, also known as IFNA1, is a human gene.[1]

Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM][1]


  1. 1.0 1.1 "Entrez Gene: IFNA1 interferon, alpha 1".

Further reading

  • Conti L, Fantuzzi L, Del Cornò M; et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. PMID 15481145.
  • Bekisz J, Schmeisser H, Hernandez J; et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.
  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini reviews in medicinal chemistry. 5 (12): 1093–101. PMID 16375755.
  • Capobianchi MR, Ankel H, Ameglio F; et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer". AIDS Res. Hum. Retroviruses. 8 (5): 575–9. PMID 1381203.
  • Olopade OI, Bohlander SK, Pomykala H; et al. (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. PMID 1385305.
  • Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
  • Delcayre AX, Salas F, Mathur S; et al. (1991). "Epstein Barr virus/complement C3d receptor is an interferon alpha receptor". EMBO J. 10 (4): 919–26. PMID 1849076.
  • Tyring SK, Cauda R, Tumbarello M; et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2". Viral Immunol. 4 (1): 33–42. PMID 1905933.
  • Göttlinger HG, Dorfman T, Sodroski JG, Haseltine WA (1991). "Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3195–9. PMID 2014240.
  • Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity". Journal of biological response modifiers. 8 (5): 501–10. PMID 2552026.
  • Capon DJ, Shepard HM, Goeddel DV (1985). "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides". Mol. Cell. Biol. 5 (4): 768–79. PMID 2985969.
  • Delfraissy JF, Wallon C, Galanaud P (1988). "Interferon-alpha can synergize with interleukin 2 for human in vitro antibody response". Eur. J. Immunol. 18 (9): 1379–84. PMID 3262520.
  • Henco K, Brosius J, Fujisawa A; et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. PMID 4057246.
  • Taniguchi T, Mantei N, Schwarzstein M; et al. (1980). "Human leukocyte and fibroblast interferons are structurally related". Nature. 285 (5766): 547–9. PMID 6157095.
  • Mantei N, Schwarzstein M, Streuli M; et al. (1980). "The nucleotide sequence of a cloned human leukocyte interferon cDNA". Gene. 10 (1): 1–10. PMID 6157600.
  • Nagata S, Mantei N, Weissmann C (1981). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha". Nature. 287 (5781): 401–8. PMID 6159536.
  • Goeddel DV, Leung DW, Dull TJ; et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. PMID 6163083.
  • Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli". Nucleic Acids Res. 11 (16): 5661–9. PMID 6310510.
  • Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions". EMBO J. 3 (8): 1809–12. PMID 6479148.
  • Ameglio F, Capobianchi MR, Castilletti C; et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines". Clin. Exp. Immunol. 95 (3): 455–8. PMID 7511078.

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