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Interferon induced with helicase C domain 1
Symbols IFIH1 ; Hlcd; IDDM19; MDA-5; MDA5; MGC133047
External IDs Template:OMIM5 Template:MGI HomoloGene32535
RNA expression pattern
PBB GE IFIH1 219209 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Interferon induced with helicase C domain 1, also known as IFIH1, is a human gene.[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.[1]


  1. 1.0 1.1 "Entrez Gene: IFIH1 interferon induced with helicase C domain 1".

Further reading

  • Kang DC, Gopalkrishnan RV, Wu Q; et al. (2002). "mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 637–42. doi:10.1073/pnas.022637199. PMID 11805321.
  • Kovacsovics M, Martinon F, Micheau O; et al. (2002). "Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation". Curr. Biol. 12 (10): 838–43. PMID 12015121.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Cocude C, Truong MJ, Billaut-Mulot O; et al. (2004). "A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication". J. Gen. Virol. 84 (Pt 12): 3215–25. PMID 14645903.
  • Kang DC, Gopalkrishnan RV, Lin L; et al. (2004). "Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene". Oncogene. 23 (9): 1789–800. doi:10.1038/sj.onc.1207300. PMID 14676839.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Andrejeva J, Childs KS, Young DF; et al. (2005). "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17264–9. doi:10.1073/pnas.0407639101. PMID 15563593.
  • Yoneyama M, Kikuchi M, Matsumoto K; et al. (2005). "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity". J. Immunol. 175 (5): 2851–8. PMID 16116171.
  • Kawai T, Takahashi K, Sato S; et al. (2005). "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction". Nat. Immunol. 6 (10): 981–8. doi:10.1038/ni1243. PMID 16127453.
  • Meylan E, Curran J, Hofmann K; et al. (2005). "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus". Nature. 437 (7062): 1167–72. doi:10.1038/nature04193. PMID 16177806.
  • Lin L, Su Z, Lebedeva IV; et al. (2006). "Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis". Cell Death Differ. 13 (11): 1982–93. doi:10.1038/sj.cdd.4401899. PMID 16575407.
  • Smyth DJ, Cooper JD, Bailey R; et al. (2006). "A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region". Nat. Genet. 38 (6): 617–9. doi:10.1038/ng1800. PMID 16699517.
  • Berghäll H, Sirén J, Sarkar D; et al. (2007). "The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines". Microbes Infect. 8 (8): 2138–44. doi:10.1016/j.micinf.2006.04.005. PMID 16782388.
  • Sirén J, Imaizumi T, Sarkar D; et al. (2007). "Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines". Microbes Infect. 8 (8): 2013–20. doi:10.1016/j.micinf.2006.02.028. PMID 16797201.
  • Barral PM, Morrison JM, Drahos J; et al. (2007). "MDA-5 is cleaved in poliovirus-infected cells". J. Virol. 81 (8): 3677–84. doi:10.1128/JVI.01360-06. PMID 17267501.
  • Marinou I, Montgomery DS, Dickson MC; et al. (2007). "The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis". Arthritis Res. Ther. 9 (2): R40. doi:10.1186/ar2179. PMID 17442111.
  • Sutherland A, Davies J, Owen CJ; et al. (2007). "Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility". J. Clin. Endocrinol. Metab. 92 (8): 3338–41. doi:10.1210/jc.2007-0173. PMID 17535987.
  • Matsukura S, Kokubu F, Kurokawa M; et al. (2007). "Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 80–3. doi:10.1159/000101411. PMID 17541283.

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