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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


IC-26 structure.svg
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass345.499
3D model (JSmol)

IC-26 (WIN 1161-3) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

Human and animal studies suggest that IC-26 is around the same potency as methadone,[1][2] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potantial, but despite being found to have similar potential to methadone for development of dependence[3] it was never placed under international control as an illegal drug.


  1. Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3
  2. Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p161-163.
  3. Wolbach AB, Fraser HF. Addiction Liability of I-C-26. UNODC Bulletin on Narcotics 1963 Vol 1


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