Hypophosphatemia pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Pathophysiology

Hypophosphatemia is caused by the following three mechanisms:

  • Inadequate intake (often unmasked in refeeding after long-term low phosphate intake)
  • Increased excretion (e.g. in hyperparathyroidism)
  • Shift from extracellular to intracellular space (seen in treatment of diabetic ketoacidosis, refeeding, short-term increases in cellular demand (e.g., hungry bones syndrome) and acute respiratory alkalosis)

References

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