Herbimycin

WikiDoc Resources for Herbimycin
Articles
Most recent articles on Herbimycin Most cited articles on Herbimycin Review articles on Herbimycin Articles on Herbimycin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Herbimycin Images of Herbimycin Photos of Herbimycin Podcasts & MP3s on Herbimycin Videos on Herbimycin
Evidence Based Medicine
Cochrane Collaboration on Herbimycin Bandolier on Herbimycin TRIP on Herbimycin
Clinical Trials
Ongoing Trials on Herbimycin at Clinical Trials.gov Trial results on Herbimycin Clinical Trials on Herbimycin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Herbimycin NICE Guidance on Herbimycin NHS PRODIGY Guidance FDA on Herbimycin CDC on Herbimycin
Books
Books on Herbimycin
News
Herbimycin in the news Be alerted to news on Herbimycin News trends on Herbimycin
Commentary
Blogs on Herbimycin
Definitions
Definitions of Herbimycin
Patient Resources / Community
Patient resources on Herbimycin Discussion groups on Herbimycin Patient Handouts on Herbimycin Directions to Hospitals Treating Herbimycin Risk calculators and risk factors for Herbimycin
Healthcare Provider Resources
Symptoms of Herbimycin Causes & Risk Factors for Herbimycin Diagnostic studies for Herbimycin Treatment of Herbimycin
Continuing Medical Education (CME)
CME Programs on Herbimycin
International
Herbimycin en Espanol Herbimycin en Francais
Business
Herbimycin in the Marketplace Patents on Herbimycin
Experimental / Informatics
List of terms related to Herbimycin

Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

It was originally found by its herbicidal activity, and thus named.

Synonyms

• Antibiotic Tan 420F
• Herbimycin A

Biological activity

Herbimycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90.

See also

• Geldanamycin