Hepatocellular carcinoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]
Overview
The majority of patients with are asymptomatic hepatocellular carcinoma during the early stages of the disease. Symptoms of hepatocellular carcinoma include abdominal pain, nausea, vomiting, weakness, jaundice, pruritus, splenomegaly, fatigue, hematemesis, fever, and loss of appetite.
History and Symptoms
- The majority of patients with hepatocellular carcinoma are asymptomatic during the early stages of the disease.
Social history
- History of alcohol use:
- Amount
- Duration
- History of illicit drug use
- History of unprotected sexual intercourse
Past Medical history
- History of infections:[1]
- History of autoimmune disorders:
- History of blood transfusions
- History of jaundice
Menstrual history
- History of menstrual irregularities
Family history
- Family history of liver disease:
Medication history
- History of use of any hepatotoxic drugs
- History of use of contraceptive hormones
Occupational History
- Industrial exposure to possible carcinogenic drugs
Common Symptoms
Patients are usually asymptomatic during the early stages of the disease. When the tumor increases in size, patients may notice one or more of the following symptoms:
- Abdominal pain
- Abdominal fullness
- Cough due to pleural effusion
- Constipation
- Coma
- Diarrhea
- Fatigue
- Fever
- Fetor hepaticus
- Forgetfulness
- Hepatic encephalopathy
- Hematemesis
- Hypoglycemia
- Jaundice and pruritus due to hepatocellular necrosis and obstruction of the bile ducts
- Loss of appetite
- Lower limbs edema
- Nausea
- Portal Hypertension
- Personality changes
- Vomiting
- Weight loss
Videos
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References
- ↑ Flores YN, Lang CM, Salmerón J, Bastani R (2012). "Risk factors for liver disease and associated knowledge and practices among Mexican adults in the US and Mexico". J Community Health. 37 (2): 403–11. doi:10.1007/s10900-011-9457-4. PMID 21877109.