Hepatitis E history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. ; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. 
Acute HEV infection is often asymptomatic. When present, symptoms develop 3 to 8 weeks after exposure to the virus and may include: muscle and joint pain, weakness, abdominal pain, nausea and vomiting, yellowish discoloration of the eyes and skin, clay-colored bowel movements, and dark-colored urine.
History and Symptoms
Most patients with hepatitis E, especially children with the disease, are asymptomatic. If symptoms occur, the average time is 3 to 8 weeks after exposure, with an average of 40 days. For patients with symptomatic disease, common symptoms may include:
- Muscle pain
- Joint pain
- Muscle weakness
- Yellowish discoloration of the eyes and skin
- Clay-colored bowel movements
- Dark-colored urine
- Prolonged cholestasis (60% patients)
- Lack of appetite
- Abdominal pain
- Skin rash
- ↑ Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J; et al. (2012). "Hepatitis E." Lancet. 379 (9835): 2477–88. doi:10.1016/S0140-6736(11)61849-7. PMID 22549046.
- ↑ Chau TN, Lai ST, Tse C; et al. (2006). "Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A". Am. J. Gastroenterol. 101 (2): 292–6. doi:10.1111/j.1572-0241.2006.00416.x. PMID 16454833.
- ↑ Wedemeyer H, Pischke S, Manns MP (2012). "Pathogenesis and treatment of hepatitis e virus infection". Gastroenterology. 142 (6): 1388–1397.e1. doi:10.1053/j.gastro.2012.02.014. PMID 22537448.