Hepatitis E history and symptoms

Jump to navigation Jump to search

Hepatitis E Microchapters


Patient Information


Historical Perspective



Epidemiology and Demographics

Risk Factors


Differentiating Hepatitis E from other Diseases

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings


Medical Therapy


Cost-Effectiveness of Therapy

Future or Investigational Therapies

Hepatitis E history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Hepatitis E history and symptoms

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hepatitis E history and symptoms

CDC on Hepatitis E history and symptoms

Hepatitis E history and symptoms in the news

Blogs on Hepatitis E history and symptoms

Directions to Hospitals Treating Hepatitis E

Risk calculators and risk factors for Hepatitis E history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]


Acute HEV infection is often asymptomatic. When present, symptoms develop 3 to 8 weeks after exposure to the virus and may include: muscle and joint pain, weakness, abdominal pain, nausea and vomiting, yellowish discoloration of the eyes and skin, clay-colored bowel movements, and dark-colored urine.

History and Symptoms

Most patients with hepatitis E, especially children with the disease, are asymptomatic. If symptoms occur, the average time is 3 to 8 weeks after exposure, with an average of 40 days. For patients with symptomatic disease, common symptoms may include:[1][2][3]


  1. Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J; et al. (2012). "Hepatitis E." Lancet. 379 (9835): 2477–88. doi:10.1016/S0140-6736(11)61849-7. PMID 22549046.
  2. Chau TN, Lai ST, Tse C; et al. (2006). "Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A". Am. J. Gastroenterol. 101 (2): 292–6. doi:10.1111/j.1572-0241.2006.00416.x. PMID 16454833.
  3. Wedemeyer H, Pischke S, Manns MP (2012). "Pathogenesis and treatment of hepatitis e virus infection". Gastroenterology. 142 (6): 1388–1397.e1. doi:10.1053/j.gastro.2012.02.014. PMID 22537448.