Haff disease laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
The diagnostic criteria for defining a case of Haff disease include a history of consumption of cooked seafood within 24 hours prior to the onset of symptoms, elevated serum CPK, and CK-MB fraction of less than 5%. Evaluation of Haff disease should include CBC, creatine kinase, serum electrolytes, liver function test, urine pH, and urinalysis.
Laboratory findings
Since Haff disease causes rhabdomyolysis, the approach to the evaluation of rhabdomyolysis should be as follows:
- CBC (complete blood count)
- Creatine kinase (three-five times the upper limit of normal values of 100 to 400 IU/L)[1]
- Chemistries (hyperkalemia, hyperphosphatemia, and hypocalcemia)
- Liver function test
- Urine pH
- Urinalysis
- Blood (+)
- No red blood cells on microscopy (seen in either hemoglobinuria or myoglobinuria)
Currently, the following diagnostic criteria is used to define cases of Haff disease:[2]
- A history of consumption of cooked seafood within 24 hours prior to the onset of symptoms
- Elevated serum creatine phosphokinase (more than fivefold)
- CK-MB fraction of <5%
References
- ↑ "StatPearls". 2022. PMID 28846335.
- ↑ Pei P, Li XY, Lu SS, Liu Z, Wang R, Lu XC; et al. (2019). "The Emergence, Epidemiology, and Etiology of Haff Disease". Biomed Environ Sci. 32 (10): 769–778. doi:10.3967/bes2019.096. PMID 31843046.