HYPER-CVAD regimen

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Synonyms and keywords: Hyper-Cyclophosphamide-Vincristine-Adriamycin-Dexamethasone regimen

Overview

HYPER-CVAD regimen refers to a regimen consisting of cyclophosphamide, vincristine, doxorubicin (Adriamycin), and dexamethasone used to treat some forms of Burkitt's lymphoma, diffuse large B-cell lymphoma, and multiple myeloma.^[1]^[2]^[3]

Regimen

CCyclophosphamide

VVincristine (Oncovin)

ADoxorubicin (Adriamycin)

DDexamethasone

Indications

References

↑ ^1.0 ^1.1 Morgan GJ, Davies FE, Gregory WM, Bell SE, Szubert AJ, Navarro Coy N; et al. (2012). "Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results". Haematologica. 97 (3): 442–50. doi:10.3324/haematol.2011.043372. PMC 3291601. PMID 22058209.
↑ ^2.0 ^2.1 Oki Y, Westin JR, Vega F, Chuang H, Fowler N, Neelapu S; et al. (2013). "Prospective phase II study of rituximab with alternating cycles of hyper-CVAD and high-dose methotrexate with cytarabine for young patients with high-risk diffuse large B-cell lymphoma". Br J Haematol. 163 (5): 611–20. doi:10.1111/bjh.12585. PMID 24117234.
↑ ^3.0 ^3.1 Thomas DA, Faderl S, O'Brien S, Bueso-Ramos C, Cortes J, Garcia-Manero G; et al. (2006). "Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia". Cancer. 106 (7): 1569–80. doi:10.1002/cncr.21776. PMID 16502413.

[pmid22058209-1] 1.0 ^1.1 Morgan GJ, Davies FE, Gregory WM, Bell SE, Szubert AJ, Navarro Coy N; et al. (2012). "Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results". Haematologica. 97 (3): 442–50. doi:10.3324/haematol.2011.043372. PMC 3291601. PMID 22058209.

[pmid24117234-2] 2.0 ^2.1 Oki Y, Westin JR, Vega F, Chuang H, Fowler N, Neelapu S; et al. (2013). "Prospective phase II study of rituximab with alternating cycles of hyper-CVAD and high-dose methotrexate with cytarabine for young patients with high-risk diffuse large B-cell lymphoma". Br J Haematol. 163 (5): 611–20. doi:10.1111/bjh.12585. PMID 24117234.

[pmid16502413-3] 3.0 ^3.1 Thomas DA, Faderl S, O'Brien S, Bueso-Ramos C, Cortes J, Garcia-Manero G; et al. (2006). "Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia". Cancer. 106 (7): 1569–80. doi:10.1002/cncr.21776. PMID 16502413.

[1]

[2]

[3]

HYPER-CVAD regimen

Overview

Regimen

Indications

References

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