HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1gene.[1][2][3]
HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:
ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
promotes synaptonemal-complex formation independently of its role in homology search.
plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)
↑Chen YT, Venditti CA, Theiler G, Stevenson BJ, Iseli C, Gure AO, Jongeneel CV, Old LJ, Simpson AJ (Jul 2005). "Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein". Cancer Immun. 5: 9. PMID15999985.
Pangas SA, Yan W, Matzuk MM, Rajkovic A (2006). "Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein". Gene Expr. Patterns. 5 (2): 257–63. doi:10.1016/j.modgep.2004.07.008. PMID15567723.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
