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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR51
Haplotypes groups DRA*01:DRB5*01 DRA*01:DRB5*02
Structure (See HLA-DR)
alpha *0101
Symbol(s) HLA-DRA
beta 5 *01 *02
Symbol(s) HLA-DRB5
Shared data
Locus chr.6 6p21.31

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.[1] having diverged from DRB1 approximately 4 million years ago.[2]

DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.


DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.

DR52 recognition of some DRB3* alleles[3]
DRB5* DR51 ? Sample
allele % % size (N)
0101 >71 28
0102 >86 8
0202 >86 13

DRB5*01 allele group

  • 14 Alleles: 11 proteins, 2 Nulls
  • DR51 Serotype: *0101, *0102
  • Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
  • Nulls: *0108N, *0110N

DRB5*02 allele group

  • 4 Alleles: 4 proteins
  • DR51 Serotype: *0202,
  • Serotype unknown: *0203 to *0205

Associated diseases

DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:

DRB5*0101:DRB1*1501 Multiple schlerosis[4], leprosy[5]

DRB1 linkage

HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.



  1. Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics. 25 (6): 397–402. PMID 3596674.
  2. Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23–31. PMID 8911994.
  3. derived from IMGT/HLA
  4. Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R (2006). "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype". J Immunol. 176 (3): 1951–61. PMID 16424227.
  5. Joko S, Numaga J, Kawashima H, Namisato M, Maeda H (2000). "Human leukocyte antigens in forms of leprosy among Japanese patients". Int J Lepr Other Mycobact Dis. 68 (1): 49–56. PMID 10834069.