HLA-DR2

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Illustration of HLA-DR

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1* DR15 DR2 DR16 Sample
allele % % % size (N)
1501 76 23 6428
1502 77 16 676
1503 81 13 286
1504 >50 1
1505 >25 2
1507 >50 1
.
DR16 DR2 DR15 N
1601 41 29 19 703
1602 47 30 16 239
1604 >50 1

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, multiple sclerosis[2], and narcolepsy, tuberculoid leprosy[3] (multi-drug resistent tuberculosis or leprosy),[4] Hashimoto's thyroiditis[5], ulcerative colitis(Japanese)[6], primary biliary cirrhosis and autoimmune hepatitis[7]. DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetaes and chronic interstitial lung disease.[8]

Genetic linkage

DR2 is linked to the HLA-DR53.

References

  1. derived from IMGT/HLA
  2. Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. PMID 7275697.
  3. van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. PMID 6156220.
  4. Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 Suppl 1: 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
  5. Azuma Y, Sakurami T, Ueno Y, Ohishi M, Saji H, Terasaki P, Park M (1982). "HLA-DR antigens in Japanese with Hashimoto's thyroiditis and Graves' disease". Endocrinol Jpn. 29 (4): 423–7. PMID 6961032.
  6. Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. PMID 6947923.
  7. Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. PMID 6409699.
  8. Hirakata M, Suwa A, Takada T; et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.