HLA-DR15

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR15
Haplotypes groups DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1501 to *1505 *1507
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1501
EBI-HLA DRB1*1502
EBI-HLA DRB1*1503
EBI-HLA DRB1*1504
EBI-HLA DRB1*1505
EBI-HLA DRB1*1507
Shared data
Locus chr.6 6p21.31

HLA-DR15(DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1* DR15 DR2 DR16 Sample
allele % % % size (N)
1501 76 23 6428
1502 77 16 676
1503 81 13 286
1504 >50 1
1505 >25 2
1507 >50 1

Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively asscoiated goodpasture syndrome[2], early age onset multiple schlerosis[3], pernicious anaemia,[4] sarcoidosis,[5] and a predisposition for postmenopausal osteoporosis.[6]

DRB1*1501 is positively associated with Goodpasture syndrome[7][8], juvenile rheumatoid arthritis[9], allergic bronchopulmonary aspergillosis[10], multiple schlerosis[11], systemic lupus erythematosus[12], cervical cancer (human papillomavirus infection)[13], and Sjogren's syndrome associated with systemic lupus erythematosus.[14]

DRB1*1502 is associated with systemic lupus erythematosus[15], systemic sclerosis (SSc) & anti-topoisomerase antibodies.[16]

DRB1*1503 is associated with Chaga's cardiomyopathy[17], allergic bronchopulmonary aspergillosis[18], multiple sclerosis[11], cervical cancer (human papillomavirus infection).[19]


Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[19]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[15]

Genetic Linkage

DR15 Haplotypes
Serotypes DRA DRB1 DRB5
DR15(2)-DR51 *0101 *1501 *0101
*0101 *1502 *0101
*0101 *1503 *0101
*0101 *1504 *0101
*0101 *1505 *0101
*0101 *1507 *0101
DQA1 DQB1 DRB1
DR15(2)-DQ6(6.2, 1) *0102 *0602 *1501
DR15(2)-DQ6(6.1, 1) *0103 *0601 *1502
HLA-A HLA-B DRB1
A3-Cw7-B7-DR15(2) *0301 *0702 *1501
A1-B51-DR15(2) *0101 *5101 *1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

  1. derived from IMGT/HLA
  2. Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease". Int Immunol. 12 (8): 1135–43. PMID 10917888.
  3. Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis". Ann Neurol. 48 (2): 211–9. PMID 10939572.
  4. Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768–70. PMID 6783164.
  5. Bilir M, Sipahi S, Yilmaz E; et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. PMID 17458393.
  6. Douroudis K, Tarassi K, Athanassiades T; et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
  7. Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int. 68 (3): 1061–70. PMID 16105036.
  8. Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int. 56 (5): 1638–53. PMID 10571772.
  9. Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. PMID 15120191.
  10. Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
  11. 11.0 11.1 Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Jugde F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens. 61 (2): 166–71. PMID 12694585.
  12. Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". Int J Immunogenet. 32 (3): 173–8. PMID 15932622.
  13. Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet. 6 (2): 157–62. PMID 8162070.
  14. Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum. 50 (3): 882–91. PMID 15022331.
  15. 15.0 15.1 Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 59 (2): 113–7. PMID 12028537.
  16. Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. PMID 10088769.
  17. García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem. 43 (Pt 3): 214–6. PMID 16704757.
  18. Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
  19. 19.0 19.1 Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev. 9 (11): 1183–91. PMID 11097225.