HLA-DR12

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR12
Haplotypes groups DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1201 to *1203 *1206
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1201
EBI-HLA DRB1*1202
EBI-HLA DRB1*1203
EBI-HLA DRB1*1306
Shared data
Locus chr.6 6p21.31

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

Serology

DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles[1]
DRB1* DR12 DR5 DR11 Sample
allele % % % size (N)
1201 83 4 2 893 [2]
1202 89 162
1203 >50 3
1206 >50 2

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and paricularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus, [3] and undifferentiated spondyloarthritis.[4]

DRB1*1201 is associated with iritis in juvenile arthritis[5],primary antiphospholipid syndrome[6], tiopronin intolerance in rheumatoid arthritis,[7] adult chronic articular Still's disease[8]

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,[9] and narcolepsy in the Japanese population.

Extended linkage

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease[10]

DRB1*1201:DRB3*01/03: colorectal cancer[11]

Genetic Linkage

DR12 Haplotypes
Serotypes DRA DRB1 DRB3
DR11(5)-DR52 *0101 *1201 *0101
*0101 *1202 *0201
*0101 *1202 *0202
*0101 *1202 *0301
Serotypes DRB1 DQA1 DQB1
DR12(5)-DQ7 (7.5, 3) *1201 *0505 *0301
*1202 *0505 *0301
DR12(5)-DQ7 (7.3, 3) *1201 *0303 *0301
DR12(5)-DQ7 (7.4, 3) *1201 *0401 *0301
DR12(5)-DQ7 (7.6, 3) *1201 *0601 *0301
Serotypes HLA-A HLA-C HLA-B DRB1
A31(19)-Cw10-B51(5)-DR12(5) *3101 *0304 *5101 *1202
A11-Cw9-B75(15)-DR12(5) *1101 *0303 *1502 *1202
A2-Cw10-B13-DR12(5) *0201 *0304 *1301 *1202

HLA-DR12 is genetically linked to DR52[12] and HLA-DQ7 serotypes.

References

  1. derived from IMGT/HLA
  2. DR8 - 2%
  3. Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus". J Invest Dermatol. 125 (5): 895–9. PMID 16297186.
  4. Liao HT, Lin KC, Chen CH; et al. (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". doi:10.1016/j.semarthrit.2007.04.004. PMID 17604825.
  5. Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children". J Rheumatol. 21 (1): 159–64. PMID 8151573.
  6. Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. PMID 7575732.
  7. Ju LY, Paolozzi L, Delecoeuillerie G; et al. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (3): 249–54. PMID 7915222.
  8. Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease". Rheumatology (Oxford). 40 (12): 1398–404. PMID 11752512.
  9. Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health. 37 (2): 357–65. PMID 17124999.
  10. Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population". Tissue Antigens. 40 (2): 90–7. PMID 1357780.
  11. Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population". Hum Immunol. 34 (1): 19–23. PMID 1356954.
  12. Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.