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Major histocompatibility complex, class II, DQ alpha 1
File:PBB Protein HLA-DQA1 image.jpg
PDB rendering based on 1jk8.
Symbols HLA-DQA1 ; GSE; CD; CELIAC1; DQ-A1; FLJ27088; FLJ27328; HLA DQA1; HLA-DQA
External IDs Template:OMIM5 Template:MGI HomoloGene7750
RNA expression pattern
File:PBB GE HLA-DQA1 212671 s at tn.png
File:PBB GE HLA-DQA1 213831 at tn.png
File:PBB GE HLA-DQA1 203290 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene.

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.[1]

See also


  1. "Entrez Gene: HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1".

Further reading

  • Schmidt H, Williamson D, Ashley-Koch A (2007). "HLA-DR15 haplotype and multiple sclerosis: a HuGE review". Am. J. Epidemiol. 165 (10): 1097–109. doi:10.1093/aje/kwk118. PMID 17329717.
  • Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229–43. PMID 1362295.
  • Piatier-Tonneau D, Gastinel LN, Amblard F; et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. PMID 1869305.
  • Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
  • Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. PMID 1978941.
  • Lee KW, Johnson AH, Hurley CK (1990). "Two divergent routes of evolution gave rise to the DRw13 haplotypes". J. Immunol. 145 (9): 3119–25. PMID 2212675.
  • Todd JA, Fukui Y, Kitagawa T, Sasazuki T (1990). "The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1094–8. PMID 2300572.
  • Kao HT, Gregersen PK, Tang JC; et al. (1989). "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3". J. Immunol. 142 (5): 1743–7. PMID 2493052.
  • Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9986–90. PMID 2513578.
  • Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. doi:10.1038/339548a0. PMID 2543930.
  • Jonsson AK, Andersson L, Rask L (1989). "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity". Immunogenetics. 30 (3): 232–4. PMID 2777341.
  • Diamond DC, Sleckman BP, Gregory T; et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
  • Turco E, Care A, Compagnone-Post P; et al. (1987). "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers". Immunogenetics. 26 (4–5): 282–90. PMID 2888727.
  • Hurley CK, Gregersen P, Steiner N; et al. (1988). "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination". J. Immunol. 140 (3): 885–92. PMID 2892884.
  • Jonsson AK, Hyldig-Nielsen JJ, Servenius B; et al. (1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes". J. Biol. Chem. 262 (18): 8767–77. PMID 3036828.
  • Liu CP, Bach FH, Wu SK (1988). "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes". J. Immunol. 140 (10): 3631–9. PMID 3129499.
  • Lock CB, So AK, Welsh KI; et al. (1988). "MHC class II sequences of an HLA-DR2 narcoleptic". Immunogenetics. 27 (6): 449–55. PMID 3259543.
  • Horn GT, Bugawan TL, Long CM; et al. (1988). "Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals". Hum. Immunol. 21 (4): 249–63. PMID 3372263.
  • Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS research. 2 (3): 163–74. PMID 3489470.
  • Schiffenbauer J, Didier DK, Klearman M; et al. (1987). "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line". J. Immunol. 139 (1): 228–33. PMID 3584986.

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