HLA-DQ9

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Illustration of HLA-DQ with peptide in the binding pocket
major histocompatibility complex, class II, DQ9
Haplotypes DQA1*0201:DQA1*0303 DQA1*0301:DQB1*0303
Structure (See HLA-DQ)
Identifiers
alpha 1 *0201 *0301
Symbol(s) HLA-DQA1
EBI-HLA DQA1*0301
EBI-HLA DQA1*0201
Identifiers
beta 1 *0303
Symbol(s) HLA-DQB1
EBI-HLA DQB1*0303
Shared data
Locus chr.6 6p21.31

HLA-DQ9 (DQ9) is an HLA-DQ split antigens also recognized by DQ3, and is specific to the HLA-DQB1*0303 gene product.


Serology

DQ2, DQ3, DQ7, DQ8, and DQ9 recognition of DRB1*0303 product[1]
DQ9 DQ3 DQ2 DQ7 DQ8 sample
% % % % % (N)
0303 67 12 11 1 1 2563

The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DBB1*group recognizes DQB1*0303 as efficiently as DQ3.

For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.

Alleles

DQB1*0303 (DQ9) is assoicated with nasal polyps,[2] gestational diabetes,[3] microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303 [4]

Haplotypes

DQ9.2

DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),[5][6]

DQ9.3

DQA1*0301:DQB1*0303 maybe associated with juvenile diabetes in the orient.[7][8] (Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303[9]

References

  1. derived from IMGT/HLA
  2. Zhai L, Sun Y, Tang L, Liu H (2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol. 116 (1): 66–8. PMID 17305280.
  3. Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population". Hum. Immunol. 65 (12): 1443–50. doi:10.1016/j.humimm.2004.09.002. PMID 15603871.
  4. Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese". Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.
  5. Schmitt-Egenolf M, Boehncke WH, Ständer M, Eiermann TH, Sterry W (1993). "Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 extended haplotype". J. Invest. Dermatol. 100 (6): 749–52. PMID 8496614.
  6. Zhang X, Wei S, Yang S; et al. (2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. Dermatol. 43 (3): 181–7. PMID 15009387.
  7. Maruyama T, Shimada A, Kasuga A; et al. (1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". Diabetes Res. Clin. Pract. 23 (2): 77–84. PMID 8070305.
  8. Ikegami H, Kawaguchi Y, Yamato E; et al. (1992). "Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab. 75 (5): 1381–5. PMID 1358911.
  9. Xia Q, Zhou WM, Liang YH; et al. (2006). "MHC haplotypic association in Chinese Han patients with vitiligo". Journal of the European Academy of Dermatology and Venereology : JEADV. 20 (8): 941–6. doi:10.1111/j.1468-3083.2006.01686.x. PMID 16922942.