HLA-DQ6

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Illustration of HLA-DQ with peptide in the binding pocket
HLA-DQ6
Haplotypes DQA1*0103:DQB1*0601 DQA1*0102:DQB1*0602 DQA1*0103:DQB1*0603 DQA1*0102:DQB1*0605 DQA1*0102:DQB1*0605 DQA1*0102:DQB1*0609
Structure
See: HLA-DQ
Identifiers
alpha 1 *0102 or *0103
EBI-HLA DQA1*0102
EBI-HLA DQA1*0103
Identifiers
beta 1 *0601 to *0611
EBI-HLA DQB1*0601
EBI-HLA DQB1*0602
EBI-HLA DQB1*0603
EBI-HLA DQB1*0604
EBI-HLA DQB1*0605
EBI-HLA DQB1*0609
Shared data
Locus chr.6 6p21.31

HLA-DQ6 is an HLA-DQ serotype grouping based on antibody recognition of the HLA DQ beta chain. It is synonymous with the HLA-DQB1*06 allelegroup. This group is composed of many similar beta chains. HLA DQB1*0601 to *0605, and *0609 are the most common. These beta chains are linked to certain alpha chain genes DQA1*01 as a result DQ6 serotyped cells were originally recognized as DQ1 since DQ1 recognizes the DQA1*01 allele group gene products. These gene products are DQA1*0101 to *0106. DQ1 also recognizes cells recognized by DQ5.

Serology

DQ6, DQ1, and DQ5 recognition of some Some DQB1* alleles
DQ6 DQ1 DQ5 N
allele % % % size (N)
0601 64 23 675
0602 67 30 1 5151
0603 62 23 2 2807
0604 59 27 2 1592
0605 76 13 358
0609 48 32 3 149

Alleles

DQB1*0601, *0602, *0603, *0604, *0605 and DQB1*0609 are the most common. DQB1*0601 is generally linked to DQA1*0103 as DQ6.1 and is more common in eastern asia. DQB1*0602 is commonly lined to DQA1*0102 as DQ6.2 and is common from central asia into Western Europe, *0602 is also linked to DQA1*0103 in parts of Asia. DQB1*0603 is commonly lined to DQA1*0103 as DQ6.3 and is common from Central asia into Western Europe, *0603 is also linked to DQA1*0102 in parts of Asia. DQB1*0604 is found at higher frequencies in parts of Asia and is linked almost exclusively to DQA1*0102 as DQ6.4. DQB1*0605 and *0609 are elevated in SW europe and Africa and are linked to DQA1*0102 as DQ6.5 and DQ6.9, respectively.

Haplotypes

DQ6.1

DQA1*0103:DQB1*0601 (DQ6.1) is found at increased freqeuncies in Asia and is almost absent in Western Europe. It confers protection from Narcolepsy[1], Type 1 diabetes[2][3], Vogt-Koyanagi-Harada (VKH) syndrome[4], pemphigus vulgaris[5], Multiple schlerosis[6], myasthenia gravis.

DQ6.2

DQA1*0102:DQB1*0602 (DQ6.2) is very common in eurasia, particularly central asia and eastern europe.

hypocretin deficiency associated narcolepsy - with DR15 [1][7]

Myasthenia gravis - α34-49 of AChR recognition[8]

Cervical neoplasia - DQA1*0102 - increased risk - [9]

Primary biliary cirrhosis - Protective. [10]

Multiple sclerosis - DQA1*0102 was the most frequent allele in the MS patients and DQB1*0602 increased significantly in the MS patients.[11][12]

DQ6.3

A1*0103:B1*0603 (DQ6.3) is found in northcentral europe at moderate frequencies, it is a protective against many autoimmune diseases.

DQ6.4

A1*0102:B1*0604 (DQ6.4) is associated with thymoma induced myastenia gravis[13].

References

  1. 1.0 1.1 Hong SC, Lin L, Lo B; et al. (2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
  2. Sang Y, Yan C, Zhu C, Ni G (2001). "Relationship between HLA-DRB1 and DQ alleles and the genetic susceptibility to type 1 diabetes". Chin. Med. J. 114 (4): 407–9. PMID 11780465.
  3. Saruhan-Direskeneli G, Uyar FA, Bas F; et al. (2000). "HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey". Hum. Immunol. 61 (3): 296–302. PMID 10689119.
  4. Kim MH, Seong MC, Kwak NH; et al. (2000). "Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans". Am. J. Ophthalmol. 129 (2): 173–7. PMID 10682969.
  5. Niizeki H, Inoko H, Mizuki N; et al. (1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. 44 (4): 248–51. PMID 7871526.
  6. Amirzargar A, Mytilineos J, Yousefipour A; et al. (1998). "HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patients". Eur. J. Immunogenet. 25 (4): 297–301. PMID 9777330.
  7. Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. PMID 14592217.
  8. Deitiker PR, Oshima M, Smith RG, Mosier DR, Atassi MZ (2006). "Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis". Autoimmunity. 39 (4): 277–88. doi:10.1080/08916930600738581. PMID 16891216.
  9. Schiff MA, Apple RJ, Lin P, Nelson JL, Wheeler CM, Becker TM (2005). "HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women". Hum. Immunol. 66 (10): 1050–6. doi:10.1016/j.humimm.2005.09.002. PMID 16386646.
  10. Mullarkey ME, Stevens AM, McDonnell WM; et al. (2005). "Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis". Tissue Antigens. 65 (2): 199–205. doi:10.1111/j.1399-0039.2005.00351.x. PMID 15713222.
  11. Amirzargar AA, Tabasi A, Khosravi F; et al. (2005). "Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study". Eur. J. Neurol. 12 (1): 25–30. doi:10.1111/j.1468-1331.2004.00901.x. PMID 15613143.
  12. Fernández O, Fernández V, Alonso A; et al. (2004). "DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain". J. Neurol. 251 (4): 440–4. doi:10.1007/s00415-004-0350-2. PMID 15083289.
  13. Vieira M, Caillat-Zucman S, Gajdos P, Cohen-Kaminsky S, Casteur A, Bach J (1993). "Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis". J Neuroimmunol. 47 (2): 115–22. PMID 8370765.

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