HLA-DQ5

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Illustration of HLA-DQ with peptide in the binding pocket
HLA-DQ5
Haplotypes DQA1*0101:DQB1*0501 DQA1*0102:DQB1*0502 DQA1*0104:DQB1*0503
Structure
See: HLA-DQ
Identifiers
alpha 1 *0101 *0102 *0104
EBI-HLA DQA1*0101
EBI-HLA DQA1*0102
EBI-HLA DQA1*0104
Identifiers
beta 1 *0501 to *0504
EBI-HLA DQB1*0501
EBI-HLA DQB1*0502
EBI-HLA DQB1*0503
EBI-HLA DQB1*0504
Shared data
Locus chr.6 6p21.31

HLA-DQ5 (DQ5) is a HLA-DQ serotype that recognizes the beta chain varaints encoded by the HLA-DQB1*05 subgroup. DQ5 is synonymous with HLA-DQB1*05. The serotype recognizes with moderate efficiency the gene products of the DQB1*0501, *0502, *0503, *0504 alleles. DQ5 is a split antigen of the older HLA-DQ1 which recognized the alpha chain of DQ.

Serology

DQ5, DQ1, and DQ6 recognition of some Some DQB1* alleles >[1]
DQB1* DQ5 DQ1 DQ6 Sample
allele % % % size (N)
0501 69 20 2 5536
0502 48 24 15 919
0503 58 22 4 1327
0504 59 17 2 48

The efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ5 recognition is relatively low and error prone.

While DQ5 recognizes DQB1*05 alleles more efficiently than DQ1, the serotyping is rather poor method of typing for transplantation or disease association prediction or study.

Disease associations

By serotype

DQ5 is negatively associated with DQ5 Idiopathic nephrotic syndrome in Polish children, [2], and adrenocortical failure (Addison's disease)[3].

A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely[4], AIDP type of Guillain Barré syndrome,[5] and irritable bowel disease [6] but not crohn's disease in the same (jewish) population. Other studies show DQ5 is associated with extrachromosomal manifestations of Crohn's.[7]

DQ5 appears to be associated with Analgesic intolerance[8]

By haplotype

MuSK antibody-positive myasthenia gravis HLA-DR14-DQ5 [9], probably DRB1*1402:DQA1*0104:DQB1*0503. DR1-DQ5 is associated with acid anyhydride sensitivity[10]

References

  1. derived from IMGT/HLA
  2. Krasowska-Kwiecień A, Sancewicz-Pach K, Moczulska A (2006). "Idiopathic nephrotic syndrome in Polish children - its variants and associations with HLA". Pediatr. Nephrol. 21 (12): 1837–46. doi:10.1007/s00467-006-0271-7. PMID 16967287.
  3. Myhre AG, Undlien DE, Løvås K; et al. (2002). "Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features". J. Clin. Endocrinol. Metab. 87 (2): 618–23. PMID 11836294.
  4. Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality". Surgical neurology. 66 Suppl 1: S25–8, discussion S28-9. doi:10.1016/j.surneu.2006.06.048. PMID 16904993.
  5. Guo L, Wang W, Li C, Liu R, Wang G (2002). "[The association between HLA typing and different subtypes of Guillain Barré syndrome]". Zhonghua Nei Ke Za Zhi (in Chinese). 41 (6): 381–3. PMID 12137599.
  6. Trachtenberg EA, Yang H, Hayes E; et al. (2000). "HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations". Hum. Immunol. 61 (3): 326–33. PMID 10689124.
  7. Hesresbach D, Alizadeh M, Bretagne JF; et al. (1996). "Investigation of the association of major histocompatibility complex genes, including HLA class I, class II and TAP genes, with clinical forms of Crohn's disease". Eur. J. Immunogenet. 23 (2): 141–51. PMID 8732477.
  8. Kalyoncu AF, Karakaya G, Yilmaz E, Balci B, Karaduman A, Yasavul U (2003). "Analgesic intolerance with or without bronchial asthma: is there a marker?". Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. 13 (3): 162–9. PMID 14635465.
  9. Niks EH, Kuks JB, Roep BO; et al. (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology. 66 (11): 1772–4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963.
  10. Jones MG, Nielsen J, Welch J; et al. (2004). "Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acid anhydrides". Clin. Exp. Allergy. 34 (5): 812–6. doi:10.1111/j.1365-2222.2004.1956.x. PMID 15144476.