HIV-1 protease

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HIV-1 Protease (blue) complexed with inhibitor (yellow)
HIV-1 Protease
Identifiers
Symbol HIV PR
PDB 1EBZ
Other data
EC number 3.4.23

HIV-1 protease is an aspartyl protease that is essential for the life-cycle of HIV. Inhibition of this protease prevents maturation of HIV particles. As such, many drugs have been developed, so-called protease inhibitors, that target this enzyme.[1] Because HIV is a retrovirus, the active site of this enzyme will change occasionally due to mutations. To combat this, a cocktail of drugs must be used rather than a single one.

Its protein structure has been investigated using the method of X-ray crystallography.

External links

References

  1. Brik A, Wong CH (2003). "HIV-1 protease: mechanism and drug discovery". Org. Biomol. Chem. 1 (1): 5–14. PMID 12929379. 

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