The ERICH5 gene is located on human chromosome 8 at 8q22.2 and spans 29 kb on the plus strand of the DNA. [1] ERICH5 contains three exons and two introns.[2] ERICH5 is also known as C8orf47 and Glutamate Rich 5.[1]
Protein
Isoforms
The ERICH5 protein has two isofroms. The longest isofrom, isofrom 1, spans 1,550 base pairs and is composed of 374 amino acids. The second isoform lacks the third and final exon and is 596 base pairs long.[2]
Domains and motifs
ERICH5 contains one conserved domain, a domain of unknown function called DUF4573.[3] ERICH5 is predicted to contain two highly conserved motifs, an APC/C binding motif and the LIG_FHA_2 motif.[4] The APC/C motif spans amino acid 222-226 and serves as a binding site for the Anaphase- promoting complex.[5] The LIG_FHA_2 motif is involved in the cell checkpoint pathway and is found in many proteins localized in the nucleus that regulate cell cycle.[6]
True orthologs of ERICH5 have only been identified among mammalian species. The most distantly related mammalian ortholog is the Monodelphis domestica or the Gray Short Tailed Opossum.[16]
Species Name
Common Names
MYA
% Similarity
% Identity
Accession #
Protein Length
Acinonyx jubatus
Cheetah
96
71%
65%
XP_014937513.1
358
Cerathotherium
White Rhino
96
71%
66%
XP_004431343.2
358
Trichechus manatus latirostris
Manatee
105
68%
59%
XP_004370879.3
342
Monodelphis
Gray Short tailed opossum
159
40%
28%
XP_007488209.1
478
Distant orthologs
ERICH5 has distant orthologs among birds and reptiles. These distant orthologs contain only the third exon of ERICH5.[17]
