Glipizide overdose
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdose Information
General
Manifestatoins
Treatment
General
There is no well-documented experience with Glipizide overdosage in humans. There
have been no known suicide attempts associated with purposeful overdosing with Glipizide. In nonclinical studies the acute oral toxicity of glipizide was extremely low in all species
tested (LD50 greater than 4 g/kg). Return to top
Manifestatoins
Overdosage of sulfonylureas including glipizide can produce hypoglycemia. Return to top
Treatment
If hypoglycemic coma is diagnosed or suspected, the patient should be given
rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a
continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood
glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to
48 hours since hypoglycemia may recur after apparent clinical recovery. Clearance of glipizide
from plasma may be prolonged in persons with liver disease. Because of the extensive protein
binding of glipizide, dialysis is unlikely to be of benefit. Return to top
Adapted from the FDA Package Insert.